What is the Joint Center for Structural Genomics (JCSG)?

JCSG is a multi-institutional consortium and a Production Center of the NIH Protein Structure Initiative (PSI), focused on high-throughput determination of three-dimensional protein structures.

How many protein structures has JCSG solved?

JCSG has solved more than 1,600 protein structures, with over 1,500 unique targets deposited in the Protein Data Bank (PDB).

Which institutions are part of the JCSG consortium?

The consortium includes The Scripps Research Institute (TSRI), the San Diego Supercomputer Center (SDSC), Stanford Synchrotron Radiation Lightsource (SSRL), the University of California San Diego (UCSD), the Genomics Institute of the Novartis Research Foundation (GNF), the Sanford-Burnham Medical Research Institute, and the Center for Research in Biological Systems (CRBS).

What tools and resources does JCSG provide?

JCSG provides tools and datasets including the Structure Gallery, BLAST vs. JCSG Targets, HMM vs. PSI Families, XtalPred, qFit, Pubserver, the Ligand Server, and the QC Server, along with crystallographic datasets and publications.

Are JCSG structures publicly available?

Yes. JCSG deposits all solved protein structures in the worldwide Protein Data Bank (PDB) and shares datasets, tools, and publications openly with the scientific community.

Three-dimensional ribbon diagram of a protein structure determined by the Joint Center for Structural Genomics, illustrating high-throughput structural biology research. — Protein ribbon model representative of structures solved by JCSG as part of the NIH Protein Structure Initiative.

PSI Production Center

The JCSG Production Center for the Protein Structure Initiative

The Joint Center for Structural Genomics applies high-throughput methods to determine three-dimensional protein structures and expand coverage of the protein structure universe.

Our Pipeline JCSG Resources

JCSG Target Scoreboard

Total Structures Solved: 1,601
Targets in PDB: 1,519
Structures in PDB: 1,600

What JCSG Delivers

Technology, structures, and annotations supporting the global structural biology community.

Technology and Methodology

JCSG has developed and integrated new technologies covering the gene-to-structure process to enable high-throughput structural biology at scale.

Explore the pipeline →

Structure Gallery

JCSG has determined high-resolution structures of more than 1,000 proteins — many are first structural representatives of uncharacterized protein families.

Browse structures →

Functional Annotation

Through TOPSAN, a Wiki-based information and annotation portal, the community collaboratively annotates protein structures solved by structural genomics centers.

About TOPSAN →

Consortium Partners

Stay Informed

JCSG Tools

Leadership & Principal Investigators

JCSG is led by an interdisciplinary team of investigators across its consortium institutions.

Ian A. Wilson
Director & Principal Investigator
The Scripps Research Institute (TSRI)
Scott A. Lesley
Co-Principal Investigator
Genomics Institute of the Novartis Research Foundation (GNF)
Adam Godzik
Co-Principal Investigator
Sanford-Burnham Medical Research Institute
Ashley M. Deacon
Co-Principal Investigator
Stanford Synchrotron Radiation Lightsource (SSRL)
Marc-André Elsliger
Co-Investigator
The Scripps Research Institute (TSRI)

Insights & Articles

Explore how structural genomics underwrites modern peptide therapeutics and protein science.

Structural Genomics & Peptide Drug Discovery

How high-throughput structural genomics pipelines accelerate the design, optimisation, and validation of peptide-based therapeutics.

Understanding Protein–Peptide Interactions

A clear, structure-first explanation of how proteins and peptides recognise one another, and why those interactions matter.

How Protein–Peptide Interactions Shape Cellular Function

Protein–peptide interactions orchestrate signalling, trafficking, and gene regulation across the cell.

The Role of Structural Genomics in Peptide Drug Discovery

Why structural genomics is the quiet engine behind modern peptide therapeutics — from target validation to clinical candidate selection.

Protein–Peptide Interactions in Structural Genomics

How structural genomics consortia characterise protein–peptide interactions and feed the data back into therapeutic design.

From Protein Structures to Peptide Therapeutics

Tracing the workflow that converts a deposited protein structure into a marketed peptide drug.

Learn More About JCSG

Explore the consortium's mission, meet the investigators, and get in touch with the JCSG team.

Frequently Asked Questions

What is the Joint Center for Structural Genomics (JCSG)?: JCSG is a multi-institutional consortium and a Production Center of the NIH Protein Structure Initiative (PSI), focused on high-throughput determination of three-dimensional protein structures.
How many protein structures has JCSG solved?: JCSG has solved more than 1,600 protein structures, with over 1,500 unique targets deposited in the Protein Data Bank (PDB).
Which institutions are part of the JCSG consortium?: The consortium includes The Scripps Research Institute (TSRI), the San Diego Supercomputer Center (SDSC), Stanford Synchrotron Radiation Lightsource (SSRL), the University of California San Diego (UCSD), the Genomics Institute of the Novartis Research Foundation (GNF), the Sanford-Burnham Medical Research Institute, and the Center for Research in Biological Systems (CRBS).
What tools and resources does JCSG provide?: JCSG provides tools and datasets including the Structure Gallery, BLAST vs. JCSG Targets, HMM vs. PSI Families, XtalPred, qFit, Pubserver, the Ligand Server, and the QC Server, along with crystallographic datasets and publications.
Are JCSG structures publicly available?: Yes. JCSG deposits all solved protein structures in the worldwide Protein Data Bank (PDB) and shares datasets, tools, and publications openly with the scientific community.